QALQONSIMON BEZ DISFUNKSIYASI BO’LGAN BEMORLARDA YURAK ISHEMIK KASALLIGINING KLINIK KECHISHINI PRAGNOZ QILISH
Toshkent Tibbiyot Akademiyasi 1-son “Oilaviy tibbiyotda ichki kasalliklar va preventiv tibbiyot asoslari” kafedrasi, dotsent Shukurjanova Surayyo Mahmudovna taqrizi ostida
Keywords:
qalqonsimon bez garmonlari, gipotiroidizm, gipertiriodizm, yurak ishemik kasalligi, giperlipidemiya, trombogenez, mitoxondrial regulyator, qon bosimi.Abstract
Qalqonsimon bez metabolizm, shuningdek, yurak faoliyati va periferik qon tomir tizimi uchun javobgardir. Qalqonsimon bezning disfunktsiyasi yurak qisqarishi, insult xavfi, yurak tezligi, periferik qon tomirlarining qarshiligi va elektr faolligini buzish orqali yurak-qon tomir kasalliklari, shu jumladan yurak yetishmovchiligi va koronar yurak kasalligi va aritmiyalar xavfining oshishi bilan bog'liq. Qalqonsimon bezning disfunktsiyalari ateroskleroz, gipertenziya va dislipidemiya kabi bir qator yurak-qon tomir xavf omillarining ham sababchidir, shuningdek, atriyal fibrilatsiya bilan bog'liq bo'lgan aritmiyani keltirib chiqaradi. Qalqonsimon bez gormonlari miokardning diastolik bo'shashishini va sistolik miokard qisqarishini ta’monlaydi. Qon tomirlarga ham ta'sir ko’rsatadi va hujayradan tashqari matritsani saqlashda muhim rol o'ynaydi. Qalqonsimon bez gormonlari yurak mitoxondrial funktsiyasini modulyatsiya qiladi. Qalqonsimon bezning disfunktsiyasi miyokardning bioenergetik holatini buzadi. Ochiq va subklinik gipotiroidizm koronar hodisalarning yuqori chastotasi va yurak etishmovchiligining rivojlanish xavfining oshishi bilan bog'liq.
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