CHRONIC DISEASE ANEMIA IN DIABETES
Keywords:
diabetes mellitus, iron deficiency anemia, anemia of chronic disease, soluble transferrin receptor.Abstract
A total of 135 patients were examined: 51 people with type 1 diabetes and 84 with type 2 diabetes. After establishing the type of anemia, the patients were stratified into groups: 1) patients with ACD; 2) patients with IDA; 3) patients with latent iron deficiency; 4) patients without ferrokinetic disorders. As a result of ROC analysis in the general sample of patients with diabetes mellitus, the following parameters showed high information content in the diagnosis of ACD: ESR — sensitivity 92%, specificity 85% with a diagnostic threshold of 26.5 mm/h (area under the curve 0.943; p<0.0001), leukocyte count — sensitivity 69%, specificity 64% with a diagnostic threshold of 7.50×109/l (area under the curve 0.727; p=0.007), MAU — sensitivity 71%, specificity 72% with a diagnostic threshold of 29.5 mg/l (area under the curve 0.744; p=0.003).
References
1. Martynov SA, Shestakova MV, Shilov EM, et al. Prevalence of anemia in patients with type 1 and type 2 diabetes mellitus with chronic renal disease. Diabetes mellitus. 2017; 20(5):318-328. (In Russ.)]. doi: https://doi.org/10.14341/DM9369
2. Thomas MC, MacIsaac RJ, Tsalamandris C, et al. Anemia in Patients with Type 1 Diabetes. J Clin Endocrinol Metab. 2014;89(9):4359-4363. doi: https://doi.org/10.1210/jc.2004-0678
3. Thomas MC, MacIsaac RJ, Tsalamandris C, et al. The burden of anemia in type 2 diabetes and the role of nephropathy: a cross-sectional audit. Nephrol Dial Transplant. 2014;19(7):1792-1797. doi: https://doi.org/10.1093/ndt/gfh248
4. Kufelkina T.Yu., Valeeva F.V. Anemia in patients with type 1 diabetes mellitus // Diabetes mellitus. - 2010. - Vol. 13. - No. 4 -P. 49-53. [Kufelkina TYu, Valeeva FV. Anemia in patients with type 1 diabetes mellitus Diabetes melitus. 2010;13(4):49-53. (In Russ.)]. doi: https://doi.org/10.14341/2072-0351-6057
