ENDOMETRIOZDA IMMUNOLOGIK OMILNING O‘RNI VA UNING KOMPLEKS DAVOLASHGA TA’SIRI
Keywords:
Endometrioz, immunologik jihatlar, patogenez, D vitamini immunitet tizimi , yallig‘lanish jarayoni, interleykinlar (IL-6, IL-8), sitokinlar, antioksidant himoya fosfolipaza A2, konservativ davolash, kombinatsiyalangan terapiya, reproduktiv yosh , bepushtlik, og‘riq sindromi.Abstract
Ushbu maqolada endometrioz kasalligining immunologik jihatlari, patogenezda immunitetning o‘rni, shuningdek, kasallikni davolashga konservativ usullar orqali D vitaminini qo‘shish orqali immun tizimini yaxshilash imkoniyatlari yoritiladi. Tadqiqot asosan, D vitaminining endometriozli bemorlarning klinik kechishini o‘zgartirishda qanday ta’sir ko‘rsatishi mumkinligini o‘rganishga bag‘ishlangan.
References
1. Parazzini, F., et al. (2017). Epidemiology of endometriosis and its comorbidities.
European Journal of Obstetrics & Gynecology and Reproductive Biology, 209, 3-7. DOI: 10.1016/j.ejogrb.2016.12.022
2. Nisenblat, V., et al. (2016). Biomarkers in endometriosis: A systematic review and meta-analysis. Fertility and Sterility, 105(1), 177-193.e10. DOI: 10.1016/j.fertnstert.2015.09.016
3. Holick, M. F. (2011). Vitamin D: Evolutionary, physiological and health perspectives.Current Drug Targets, 12(1), 4-18. DOI: 10.2174/138945011793591635
4. Lebovic, D. I., Mueller, M. D., & Taylor, R. N. (2001). Immunobiology of endometriosis. Fertility and Sterility, 75(1), 1-10. DOI: 10.1016/S0015-0282(00)016587
5. Somigliana, E., et al. (2007). Role of environmental factors in the pathophysiology of endometriosis. Reproductive BioMedicine Online, 15(1), 30-39. DOI: 10.1016/S1472-6483(10)60692-3
6. Grandi, G., et al. (2015). The association between vitamin D and endometriosis. American Journal of Obstetrics and Gynecology, 213(6), 824.e1-824.e11. DOI: 10.1016/j.ajog.2015.07.030
7. Alessandro, S., et al. (2020). Effects of vitamin D on inflammatory and antioxidant biomarkers in endometriosis: A randomized controlled trial. Journal of Endocrinological Investigation, 43(8), 1117-1126. DOI: 10.1007/s40618-020-01226-y
8. Garcia-Velasco, J. A., et al. (2002). Interleukin-6, tumor necrosis factor-alpha, and interleukin-1 receptor antagonist in peritoneal fluid and serum of women with endometriosis. Human Reproduction, 17(3), 701-705. DOI: 10.1093/humrep/17.3.701
9. Hewison, M. (2012). Vitamin D and the immune system: New perspectives on an old theme. Endocrinology and Metabolism Clinics, 41(3), 571-591. DOI: 10.1016/j.ecl.2012.04.018
10. Viganò, P., et al. (2004). Altered expression of genes involved in inflammation and immune response in the endometrium of women with endometriosis. Fertility and Sterility, 82(Supplement 3), 1089-1095. DOI: 10.1016/j.fertnstert.2004.06.046
11. Voulgaris, N., et al. (2017). "Vitamin D and inflammation: Potential implications for severity of endometriosis-associated symptoms." Human Reproduction Update, 23(3), 343-356.
12. Christodoulou, S., et al. (2020). "Vitamin D and immune modulation: A potential avenue for treating endometriosis." Journal of Clinical Medicine, 9(7), 2296.
13. Oliveira, J. F., et al. (2021). "The role of Vitamin D in immune modulation in women with endometriosis: A systematic review." Reproductive Biology and Endocrinology, 19, 45-52.
14. Arslan, A. A., et al. (2021). "Vitamin D supplementation in endometriosis: Evidence and challenges." Frontiers in Immunology, 12, 1018-1027.
15. Krzyscin, J. W., & Chankowska, M. (2019). "Anti-inflammatory effects of Vitamin D and its relevance to endometriosis." American Journal of Reproductive Immunology, 82(6), e13111.