CLINICAL AND MOLECULAR FEATURES OF STOMATITIS IN PATIENTS WITH ACUTE AND CHRONIC LEUKEMIA
Keywords:
acute and chronic leukemia, stomatitis, oral fluid, IgA antibodies and IgG antibodies to transglutaminase and gliadin.Abstract
there is an increase in such oncohematological diseases as leukemia, the incidence of which is 150-200 cases per year per 1 million people [1, 2], and among the causes of death from malignant neoplasms, they occupy 4th-5th place [3]. These are clonal neoplastic processes originating from hematopoietic cells, accompanied by their uncontrolled proliferation and disruption of the process of reproduction of mature cell populations. It is known that the balance between the processes of proliferation and cell death in the process of homeostasis is subject to regulation by a multilevel enzymatic system [4], in which the role of an apoptosis marker actually belongs to transglutaminase, accompanied by its increased expression [5]. In addition, in the process of apoptosis, individual cells undergo self-destruction, therefore, this enzyme can be considered as the main indicator of cellular renewal.
References
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